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Trexall) is a chemotherapy drug also considered a DMARD anti-rheumatic drug) used to treat rheumatoid arthritis. Near fatal drug interactions with methotrexate given for psoriasis. Br Med J (Clin Res Ed). 1987 Sep [PubMed]; Slrdal L, Sager G,. Key Words: Methotrexate etanercept NONMEM drug interaction. Address for reprints: Honghui Zhou, PhD, FCP, Clinical Pharmacology, Wyeth Research,. A significant drug interaction was suspected during the. patients first BIA Blog cycle of CODOX-M. The serum methotrexate con-. centration failed to decrease below. . protease inhibitor methotrexate

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